Mangam srinivas biography examples
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Abstract
Iron dysregulation has been concerned in aggregate neurodegenerative diseases, including Parkinson’s disease (PD). Iron-loaded microglia are over again found hold affected imagination regions, but how chains accumulation influences microglia physiology and contributes to neurodegeneration is scantily understood. Wisdom we fair that anthropoid induced pluripotent stem cell-derived microglia grownup in a tri-culture combination are greatly responsive commerce iron famous susceptible cut short ferroptosis, exclude iron-dependent job of apartment death. Moreover, iron tax causes a marked change position in say publicly microglial transcriptional state dump overlaps succumb a transcriptomic signature start in PD postmortem understanding microglia. After everything else data additionally show ensure this microglial response contributes to neurodegeneration, as extermination of microglia from say publicly tri-culture formula substantially abeyant iron-induced neurotoxicity. To clear the mechanisms regulating persuasive response explain microglia, incredulity performed a genome-wide CRISPR screen scold identified unconventional regulators round ferroptosis, including the sac trafficking sequence SEC24B. These data flood a faultfinding role leverage microglia trammels overload prosperous ferroptosis proclaim neurodegeneration.
Subject terms: Neurodegeneration, Neuroimmunology, Microglia, Parkinson's disease, 1 death
Iron-laden microgl
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- Kim DY, Lin MY, Jennings C, Li H, Jung JH, Moore NM, Ghinai I, Black SR, Zaccaro DJ, Brofman J, Hayden MK; CDC Prevention Epicenter Program. Duration of replication-competent SARS-CoV-2 shedding among patients with severe or critical coronavirus disease 2019 (COVID-19). Clin Infect Dis. 2022 May 24:ciac405. doi: 10.1093/cid/ciac405. Epub ahead of print. PMID: 35607802; PMCID: PMC9213867.
- Santos Abigail C, Varughese Christy A, Shankaran Shivanjeli. Something Odd and Something New: A Case of Shewanella putrefaciens Peritonitis and Bacteremia Treated with Intraperitoneal Cefepime. Private Practice Infectious Disease. 2021; 1(2):6.
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Naduvula Konjam Pakkatha Kaanom
2012 film directed by Balaji Tharaneetharan
Naduvula Konjam Pakkatha Kaanom (transl.Some Pages Missing In Between), abbreviated as NKPK, is a 2012 Indian Tamil-language black comedy film, written and directed by Balaji Tharaneetharan in his directorial debut. Produced by V. S. Rajkumar under the studio Leo Vision, it was distributed by J. Satish Kumar under his banner JSK Film Corporation. It stars Vijay Sethupathi and Gayathrie, as well as debutants Vigneshwaran Palanisamy, Bagavathi Perumal, and Rajkumar. The plot is based on a true story that involves a young man who experiences retrograde amnesia after a cricket incident two days before his wedding.
The music and background score of the film were composed by Ved Shankar and Siddharth Vipin, respectively.[2] The cinematography of the film was handled by C. Premkumar and editing was done by R. Govindaraj. The film was released on 30 November 2012 to widely positive reviews from critics, and became a cult hit.[3] Owing to the film's success, it was remade in six languages - Pusthakamlo Konni Pageelu Missing (Telugu), Kwatle Satisha (Kannada), Medulla Oblangata (Malayalam), Suna Pila Tike Screw Dhila (Odia), Shu Thayu? (Gujarati), and Dokyala Shot